Ozempic for Weight Loss: Risks, Side Effects, and What to Expect

GLP-1s and the Downside of Semaglutide for Weight Loss: From Muscle Loss to Metabolism Risks

For those considering Ozempic for weight loss, it’s crucial to understand the potential risks involved. Known for its effects on blood sugar levels and appetite, Ozempic has gained popularity as a weight-loss aid. However, with benefits come possible downsides. In this article, we’ll dive into the key Ozempic weight loss risks, including side effects, long-term impact, and other important considerations.

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Oh, the things I would do to stick a nice needle full of semaglutide into my stomach.

Ozempic, this so-called “miracle” diabetes medication that’s stormed its way into the weight loss scene, is everywhere—from TikToks to dinner table convos. And honestly, I get the hype. Imagine shedding pounds without constantly counting calories, with the instant “fix” that everyone keeps talking about. But even with all the temptations, I won’t be jumping on the Ozempic train anytime soon—and I have reasons that go deeper than just avoiding a quick fix.

But before I go into why this might not be the best choice for me—or for most people—let me make one thing clear. For those dealing with severe obesity or health issues tied to weight, a tool like Ozempic could be a lifeline. It’s a jumpstart, especially when losing even a small amount of weight could drastically improve health markers. And if that’s what someone needs to help them live a healthier, more active life, then no shame. Everyone’s journey is different.

I’ve struggled with my hormones since I was 15. Imagine being a 15-year-old baby (though, of course, I totally thought I had the whole world figured out back then). You can’t even drive a car yet, and you meet this stranger in a white coat with the title of “Doctor” who tells you that you have a 1% chance of having children naturally and that your hormones are basically those of a “perimenopausal 50-year-old woman”.

In all honesty, it probably only sat with me for all of 20 minutes. I didn’t even want to have kids anyway. She told me this birth control pill should solve all of my problems. So really, what was the problem?? Other than the fact that those (harsh, grueling) words were seeping… sinking deeply into my body. They sunk into the depths of my being, a trauma I didn’t even realize was now embedded in me. I carried those tiny trauma seeds with me, and now I see how they’ve grown roots in my relationship with my body.

Estrogen, stress, and that inner critic have kept me in a cycle, clinging to body fat while making it feel impossible to find a comfortable, lasting workout routine. I’m self-conscious in my skin. I don’t want to bare myself in tight workout clothes for fear of everyone critiquing the pooch that sticks out farther than most girls my age or the roll that spills out a little extra between the gap of my leggings and my tight sports bra. 

I’ve had more meltdowns (than I can count on one hand) while trying to find an outfit for a night out, and more often than not, they’ve led me to breakding down and skipping the entire event. I’ve missed out on precious moments with my beautiful, skinny friends, feeling like they could never understand my struggle to find a skirt that fit just right. It feels impossible to explain to them that those moments aren’t just about clothes; they tap into deeper insecurities.

Despite it all, I know my struggles are part of my purpose. I know that I am meant to overcome this so I can continue to share holistic and emotional healing modalities with the world. 

I know I could change all that if I just leaned into a more consistent lifestyle and mindset shift instead of pinning my hopes on Ozempic. Let’s talk about why.

The Dark Side of Ozempic’s “Quick Fix”

Recent studies show that while Ozempic can lead to rapid weight loss, it’s often not the type of weight loss we’d want if we knew the whole story. Research from a 2023 study by the American Journal of Clinical Nutrition highlights that up to 50% of weight lost on semaglutide-based medications comes from muscle mass and bone density, not just fat. While shedding a few pounds might sound appealing, losing muscle—something critical to our overall health and vitality—is not. It’s a dangerous trade-off.

So, what’s the big deal about muscle mass? It turns out, muscle isn’t just about aesthetics or strength; it’s key to our longevity and health. Studies, including one published in JAMA Network, have found that maintaining muscle mass can be a major factor in reducing risks of age-related diseases like Alzheimer’s, diabetes, and even heart disease. Muscle supports our metabolism, protects our joints, and strengthens our bones—all critical components for a long and healthy life.

Why Muscle Matters More Than the Scale

Losing muscle might mean we lose weight on the scale, but it also means losing a primary defense mechanism against chronic diseases and the natural aging process. Muscle helps regulate blood sugar, which can reduce the risk of conditions like diabetes—ironic, considering Ozempic was originally designed to treat this very disease. So, while we might achieve the short-term results of fitting into smaller jeans, the long-term impacts on our health are serious.

Here’s a scary thought: the people using Ozempic today might face an accelerated aging process in the years to come. Lower muscle mass is closely tied to frailty and reduced mobility as we age, which can lower the quality of life dramatically. Not to mention, research published in The Lancet suggests that muscle loss is closely tied to cognitive health—meaning that losing muscle can even increase the risk of cognitive decline. Muscle is like our body’s armor—it keeps us strong, helps our metabolism, protects our joints, and supports our bones. Lose too much muscle, and we compromise more than just our weight goals; we give up a core element of long-term health.

Understanding Ozempic’s Weight Loss Risks

In addition to the muscle loss, there are other risks tied to taking Semaglutide (I’m not writing this to be some fear-mongering monster, I just think it’s extremely important to consider all risks when consuming ANYTHING):

Gastrointestinal Issues:

Many users of Ozempic report side effects like nausea, vomiting, and diarrhea (I mean seriously, read those comments above). These symptoms can be uncomfortable and may lead to dehydration, negatively affecting overall health and performance in workouts. Not only do these digestive issues disrupt daily life, but they can also hinder the body’s ability to absorb essential nutrients, leading to further complications down the road.

Hair Loss:

Rapid weight loss and hormonal shifts can lead to increased shedding. This occurs due to a combination of nutrient deficiencies and the body’s stress response. When the body is in a state of shock from rapid changes, it may redirect resources away from non-essential functions like hair growth. This can leave you feeling even more self-conscious about your appearance, creating a cycle of stress and dissatisfaction.

Potential Thyroid Tumors:

Studies in rodents have indicated that semaglutide may increase the risk of thyroid C-cell tumors, although the implications for humans are still being studied. This risk is particularly concerning for those with a history of thyroid issues or a family history of thyroid cancer. The thyroid plays a crucial role in regulating metabolism, energy levels, and overall hormonal balance, making this risk one to consider seriously.

Pancreatitis Risk:

There’s a possibility of developing pancreatitis, which is inflammation of the pancreas. Symptoms can include severe abdominal pain, nausea, and vomiting. This condition can occur because semaglutide affects insulin secretion and digestive processes, creating strain on the pancreas. For those already dealing with digestive issues, this could compound their health challenges, leading to a complex and potentially dangerous situation.

Kidney Damage:

Rapid weight loss has been linked to kidney issues in some individuals. Ozempic may exacerbate this risk, especially for those with pre-existing kidney conditions. The stress of sudden weight changes can lead to dehydration and imbalances in electrolytes, further compromising kidney function. Healthy kidneys are essential for filtering waste and maintaining overall fluid balance, so any risk to them should be taken seriously.

Mental Health Effects:

The psychological impact of using a medication for weight loss can also be significant. Relying on Ozempic may lead to an unhealthy relationship with food and body image. When weight loss is solely tied to medication, it can perpetuate a mindset where success feels unattainable without it. This can lead to cycles of self-criticism and dissatisfaction, complicating one’s overall mental health journey and creating barriers to truly sustainable lifestyle changes.

Hormonal Disruption:

For someone like me, who has already faced hormone imbalances, introducing a medication like Ozempic could complicate things further. Altering hormonal pathways can have unpredictable effects, especially on mood, metabolism, and overall well-being. Disruption in hormone levels can exacerbate existing issues, making it even more challenging to achieve balance in a holistic way.

These risks weigh heavily on my mind. They serve as a reminder that the pursuit of quick fixes often comes with a price—a cost that extends far beyond the number on the scale.

Tips for Weight Loss Without Ozempic

I recently read an incredible article by Kenz on “how you can replicate ozempic results naturally”, including tips like incorporating apple cider vinegar before your meals and upping your fiber intake to help stimulate your GLP-1 production. She really nailed it here so I don’t have much to add except for a few other general (but extremely impactful) reminders!

Whole Foods:

Focus on whole, nutrient-dense foods—fruits, vegetables, lean proteins, whole grains, and healthy fats. These foods nourish your body and help you feel full.

Strength Training:

Incorporate strength training into your routine a couple of times a week. Building muscle helps maintain metabolism during weight loss.

Stay Hydrated:

Drink plenty of (filtered!!) water. Staying hydrated can help control hunger and support your metabolism.

Mindful Eating:

Slow down during meals. Pay attention to your body’s hunger cues and savor your food to avoid overeating. I personally like take 3-5 deep breaths and release the “ahhh” sound as I exhale, as well as give thanks to my food to give it some good energy before entering my body. This also helps calm my nervous system down which will aid with digestion.

Find Activities You Enjoy:

Choose physical activities that you genuinely like, whether it’s cycling, dancing, hiking, or just walking. Enjoyment is key to consistency.

Prioritize Sleep:

Aim for 7-9 hours of quality sleep each night. Lack of sleep can disrupt your appetite hormones and hinder weight loss efforts.

Manage Stress:

Stress can lead to emotional eating. Explore techniques like meditation or simple breathing exercises to help manage stress levels.

Set Realistic Goals:

Focus on gradual weight loss and building long-term habits. Celebrate small victories—each step counts.

What about for PCOS?

I’m not here to tell you what to do, I’m just here to equip you with knowledge. I know it can be so damn hard to incorporate lifestyle changes to heal (that’s exactly what sparked my idea for this article), but 

Birch recently wrote this incredible article “the sum of all things: how I healed my pcos” that is definitely worth a read (and something I have definitely bookmarked to come back to everytime I need some inspiration).

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Personally, I’m committed to a holistic approach, even though it can be incredibly challenging. I’m constantly finding myself tempted by the thought of how much easier it would be to opt for Ozempic. But I know that my focus needs to be on building strength, nurturing my body, and investing in my long-term health. This journey is all about discovering what truly works for me and embracing the process of healing and self-discovery. And if you are/going to take it, please just be conscious about properly nourishing your mind and body while doing so. <3

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I want to know your thoughts! There’s no shame or judgment here. Have you or anyone you know had any side effects from GLP-1s? Good experiences & results? Please share!